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NFL Week 8 · November 1, 2026, 1:00 PM ET

Colts vs. Jaguars Prediction & Preview

Indianapolis Colts at Jacksonville Jaguars, EverBank Stadium.

Colts vs Jaguars prediction

The odds favor the Jacksonville Jaguars: 75.1% to win (moneyline -360), with the sportsbook's margin removed. The spread is JAX -7.5 and the total 46.5. That is the market's view. Odyn's AI quant model makes its own call before kickoff: unlock the Colts vs Jaguars pick free.

Colts vs Jaguars preview

Colts vs Jaguars is an AFC South game in Week 8, Sunday, November 1 at 1:00 PM ET at EverBank Stadium on CBS. Indianapolis is 2-5 and 1-3 on the road; Jacksonville is 4-2 and has won three of four at home.

The Colts are a run-first offense around Jonathan Taylor, who has 587 rushing yards and 8 touchdowns on 140 carries, part of a 117.6 rushing yards a game average. Daniel Jones has 1,398 passing yards with 4 touchdowns and 7 interceptions, and Josh Downs leads the receivers with 26 catches for 307 yards. Indianapolis scores 22.0 points a game and allows 25.7, on 317.3 yards gained and 351.9 allowed. Tight end Tyler Warren, cornerback Sauce Gardner, quarterback Riley Leonard, receiver Anthony Gould, linebackers Bryce Boettcher and CJ Allen and guard Dalton Tucker are out; cornerback Justin Walley is questionable; receiver Alec Pierce is on injured reserve.

Jacksonville allows only 17.3 points a game, the lowest figure in this matchup, while scoring 25.7, on 359.5 yards gained and 355.2 allowed. Trevor Lawrence has 1,480 passing yards, 14 touchdowns and 4 interceptions, Bhayshul Tuten has 388 rushing yards and 2 touchdowns, and Parker Washington has 26 catches for 416 yards and 4 touchdowns. The Jaguars' report is light: safety Antonio Johnson, cornerback Montaric Brown and long snapper Ross Matiscik are questionable, and tackle Anton Harrison is on injured reserve. Odyn's AI quant model runs this game before kickoff, injury report included.

Odyn's pick

Pick drops before kickoff

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Colts vs Jaguars spread & over/under

Spread JAX -7.5 · Over/under 46.5

Lines move until kickoff.

Win probability from the odds

Colts 24.9% · Jaguars 75.1%

From the moneyline (Colts +285, Jaguars -360) with the sportsbook's margin removed. Odds move until kickoff. Check any line with the no-vig calculator, or price a multi-game ticket with the parlay calculator.

That's the sportsbook's view. Odyn's AI quant model makes its own call: members see whether it bets Colts vs Jaguars, with its win probability. Unlock the pick free for 7 days

How to watch Colts vs Jaguars

Colts vs Jaguars: team stats & injury report

Indianapolis Colts

Record2-5
Home1-2
Road1-3
Points per game22.0
Points allowed per game25.7
Yards per game317.3
Passing yards per game199.7
Rushing yards per game117.6
  • Passing: Daniel Jones (143/240, 1398 YDS, 4 TD, 7 INT)
  • Rushing: Jonathan Taylor (140 CAR, 587 YDS, 8 TD)
  • Receiving: Josh Downs (26 REC, 307 YDS)

Injury report: Anthony Gould (WR, Out); Bryce Boettcher (LB, Out); CJ Allen (LB, Out); Dalton Tucker (G, Out); Riley Leonard (QB, Out); Sauce Gardner (CB, Out); Tyler Warren (TE, Out); Justin Walley (CB, Questionable); Alec Pierce (WR, Injured Reserve)

Jacksonville Jaguars

Record4-2
Home3-1
Road1-1
Points per game25.7
Points allowed per game17.3
Yards per game359.5
Passing yards per game246.7
Rushing yards per game112.8
  • Passing: Trevor Lawrence (120/184, 1480 YDS, 14 TD, 4 INT)
  • Rushing: Bhayshul Tuten (94 CAR, 388 YDS, 2 TD)
  • Receiving: Parker Washington (26 REC, 416 YDS, 4 TD)

Injury report: Antonio Johnson (S, Questionable); Montaric Brown (CB, Questionable); Ross Matiscik (LS, Questionable); Anton Harrison (OT, Injured Reserve)

Injury reports: Colts · Jaguars · every NFL team · how the odds moved: NFL line movement.

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Updated Oct 26, 10:01 AM ET.

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