Broncos vs. Cardinals Prediction & Preview

Denver Broncos at Arizona Cardinals, State Farm Stadium.

Broncos vs Cardinals prediction

The odds favor the Denver Broncos: 67.5% to win (moneyline -238), with the sportsbook's margin removed. The spread is DEN -4.5 and the total 42.5. That is the market's view. Odyn's AI quant model makes its own call before kickoff: unlock the Broncos vs Cardinals pick free.

Broncos vs Cardinals preview

Broncos vs Cardinals sends Denver (4-2) to Arizona (2-4). The Broncos are 3-0 at home but 1-2 on the road; the Cardinals are 0-2 at home.

Denver's offense averages 19.0 points and 259.0 yards a game. Bo Nix has 1,049 yards with 6 touchdowns and 3 interceptions, J.K. Dobbins leads the rushers with 270 yards and Jaylen Waddle the receivers with 228. Linebacker Jonah Elliss, safety Talanoa Hufanga and running back Tyler Badie are out; cornerback Pat Surtain II is questionable, and running back Jonah Coleman is on injured reserve. Denver allows 20.8 points a game.

Arizona allows 29.7 points a game. Safety Andrew Wingard, running back Jeremiyah Love, guard Jon Gaines II and defensive tackle Walter Nolen III are out; safety Budda Baker, quarterback Carson Beck, defensive end Darius Robinson and cornerback Max Melton are questionable. Jacoby Brissett has 1,328 passing yards with 9 touchdowns and 6 interceptions, Tyler Allgeier leads the rushers with 157 yards, and tight end Trey McBride leads the team with 49 catches for 361 yards. Odyn's AI quant model runs this game before kickoff, injury report included.

Odyn's pick

Pick drops before kickoff

Will Odyn bet on Broncos vs Cardinals?

Members get the pick before kickoff, with the odds and the win probability.

+$1,180 at $100 a bet over the last 1,000 NFL games. Every loss counted.

Unlock the Broncos vs Cardinals pick free

7 days free · then $19.99/month · cancel anytime

Broncos vs Cardinals spread & over/under

Spread DEN -4.5 · Over/under 42.5

Lines move until kickoff.

Win probability from the odds

Broncos 67.5% · Cardinals 32.5%

From the moneyline (Broncos -238, Cardinals +195) with the sportsbook's margin removed. Odds move until kickoff. Check any line with the no-vig calculator, or price a multi-game ticket with the parlay calculator.

That's the sportsbook's view. Odyn's AI quant model makes its own call: members see whether it bets Broncos vs Cardinals, with its win probability. Unlock the pick free for 7 days

How to watch Broncos vs Cardinals

Date: Sunday, October 25, 2026
Time: 4:05 PM ET
Venue: State Farm Stadium
TV: CBS

Broncos vs Cardinals: team stats & injury report

Denver Broncos

Record	4-2
Home	3-0
Road	1-2
Points per game	19.0
Points allowed per game	20.8
Yards per game	259.0
Passing yards per game	174.8
Rushing yards per game	84.2

Passing: Bo Nix (114/189, 1049 YDS, 6 TD, 3 INT)
Rushing: J.K. Dobbins (81 CAR, 270 YDS, 2 TD)
Receiving: Jaylen Waddle (22 REC, 228 YDS, 1 TD)

Injury report: Talanoa Hufanga (S, Out); Jonah Coleman (RB, Questionable); Pat Surtain II (CB, Questionable); Jonah Elliss (LB, Injured Reserve); Tyler Badie (RB, Injured Reserve)

Arizona Cardinals

Record	2-4
Home	0-2
Road	2-2
Points per game	21.0
Points allowed per game	29.7
Yards per game	318.8
Passing yards per game	222.5
Rushing yards per game	96.3

Passing: Jacoby Brissett (156/234, 1328 YDS, 9 TD, 6 INT)
Rushing: Tyler Allgeier (53 CAR, 157 YDS, 1 TD)
Receiving: Trey McBride (49 REC, 361 YDS, 3 TD)

Injury report: Andrew Wingard (S, Out); Jeremiyah Love (RB, Out); Jon Gaines II (G, Out); Walter Nolen III (DT, Out); Budda Baker (S, Questionable); Carson Beck (QB, Questionable); Darius Robinson (DE, Questionable); Max Melton (CB, Questionable)

Injury reports: Broncos · Cardinals · every NFL team · how the odds moved: NFL line movement.

Unlock today's bets

Members see every pick, its odds and win probability

Try it free for 7 days

7 days free · then $19.99/month · cancel anytime

Updated Oct 25, 06:25 PM ET.

By the Odyn Team · 21+ · Gambling problem? Call 1-800-GAMBLER · Responsible gambling