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NFL Week 7 · October 25, 2026, 1:00 PM ET
49ers vs. Falcons Prediction & Preview
San Francisco 49ers at Atlanta Falcons, Mercedes-Benz Stadium.
49ers vs Falcons prediction
The odds favor the San Francisco 49ers: 56.3% to win (moneyline -142), with the sportsbook's margin removed. The spread is SF -2.5 and the total 50.5. That is the market's view. Odyn's AI quant model makes its own call before kickoff: unlock the 49ers vs Falcons pick free.
49ers vs Falcons preview
49ers vs Falcons sends unbeaten San Francisco (6-0, 2-0 on the road) to Atlanta (2-4). The Falcons are 0-3 at home this season and 2-1 away.
San Francisco scores 29.5 points and allows 18.3 per game. Brock Purdy has 1,460 yards with 14 touchdowns and 2 interceptions, Christian McCaffrey has 350 rushing yards and 7 touchdowns, and George Kittle leads the receivers with 337 yards and 5 touchdowns. The injury list is long: wide receivers Mike Evans and Deebo Samuel Sr., defensive end Nick Bosa, linebackers Garret Wallow and Luke Gifford and safety Marques Sigle are out; safety Siran Neal and cornerback Upton Stout are questionable.
Atlanta leans on Bijan Robinson, who has 641 rushing yards and 4 touchdowns in a run game averaging 149.5 yards. Michael Penix Jr. has 944 passing yards with 6 touchdowns and 1 interception, and Drake London has 550 receiving yards. The Falcons allow 25.5 points a game. Running back Brian Robinson Jr., cornerback Billy Bowman Jr. and linebacker Divine Deablo are out; cornerbacks C.J. Henderson and Avieon Terrell, defensive ends Za'Darius Smith and Samson Ebukam, defensive tackle Gervon Dexter Sr., linebacker Kendal Daniels and wide receiver Olamide Zaccheaus are questionable; wide receiver Beaux Collins and linemen Cameron Williams and Michael Jerrell are on injured reserve. Odyn's AI quant model runs this game before kickoff, injury report included.
Odyn's pick
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49ers vs Falcons spread & over/under
Spread SF -2.5 · Over/under 50.5
Lines move until kickoff.
Win probability from the odds
49ers 56.3% · Falcons 43.7%
From the moneyline (49ers -142, Falcons +120) with the sportsbook's margin removed. Odds move until kickoff. Check any line with the no-vig calculator, or price a multi-game ticket with the parlay calculator.
That's the sportsbook's view. Odyn's AI quant model makes its own call: members see whether it bets 49ers vs Falcons, with its win probability. Unlock the pick free for 7 days
How to watch 49ers vs Falcons
- Date: Sunday, October 25, 2026
- Time: 1:00 PM ET
- Venue: Mercedes-Benz Stadium
- TV: Fox
49ers vs Falcons: team stats & injury report
San Francisco 49ers
| Record | 6-0 |
| Home | 4-0 |
| Road | 2-0 |
| Points per game | 29.5 |
| Points allowed per game | 18.3 |
| Yards per game | 371.5 |
| Passing yards per game | 243.3 |
| Rushing yards per game | 128.2 |
- Passing: Brock Purdy (119/171, 1460 YDS, 14 TD, 2 INT)
- Rushing: Christian McCaffrey (77 CAR, 350 YDS, 7 TD)
- Receiving: George Kittle (26 REC, 337 YDS, 5 TD)
Injury report: Deebo Samuel Sr. (WR, Out); Garret Wallow (LB, Out); Luke Gifford (LB, Out); Marques Sigle (S, Out); Mike Evans (WR, Out); Nick Bosa (DE, Out); Siran Neal (S, Questionable); Upton Stout (CB, Questionable)
Atlanta Falcons
| Record | 2-4 |
| Home | 0-3 |
| Road | 2-1 |
| Points per game | 23.7 |
| Points allowed per game | 25.5 |
| Yards per game | 360.5 |
| Passing yards per game | 211.0 |
| Rushing yards per game | 149.5 |
- Passing: Michael Penix Jr. (71/110, 944 YDS, 6 TD, 1 INT)
- Rushing: Bijan Robinson (111 CAR, 641 YDS, 4 TD)
- Receiving: Drake London (31 REC, 550 YDS)
Injury report: Billy Bowman Jr. (CB, Out); Brian Robinson Jr. (RB, Out); Divine Deablo (LB, Out); Avieon Terrell (CB, Questionable); C.J. Henderson (CB, Questionable); Gervon Dexter Sr. (DT, Questionable); Kendal Daniels (LB, Questionable); Olamide Zaccheaus (WR, Questionable); Samson Ebukam (DE, Questionable); Za'Darius Smith (DE, Questionable); Beaux Collins (WR, Injured Reserve); Cameron Williams (OL, Injured Reserve); Michael Jerrell (OT, Injured Reserve)
Injury reports: 49ers · Falcons · every NFL team · how the odds moved: NFL line movement.
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Updated Oct 25, 06:25 PM ET.
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